Health & Physiology
How obesity can improve the efficacy of cancer treatment: role of the sex hormone estrogens.
Over the last decades, cancer immunotherapy has brought new hope to patients by significantly improving survival. Contrary to chemotherapy and radiotherapy that target cancer cells, immunotherapy aims to strengthen the immune system to recognize and destroy cancer cells. However, while some patients respond very well... click to read more
Rejuvenating the Aged Intestinal System
Aging disrupts the homeostasis of all tissues in the body, including the intestinal epithelium, known for its robust regenerative capacity, which is crucial for ensuring nutrient absorption and barrier protection. The key players in this regenerative mechanism are intestinal stem cells (ISCs), located at the... click to read more
Tobacco smoking and other exposures shut off cancer-fighting genes
Cancer is a genetic disease caused by mutations in DNA. Most mutations are substitutions of single nucleotides, the basic building blocks of DNA. Mutations occur over time due to natural processes like faulty DNA repair or from external sources like ultraviolet light. Researchers have discovered... click to read more
A hidden clock that times cytoplasmic divisions
Omnis cellular e cellula – all cells arise from pre-existing cells. This seemingly obvious tenet of cell theory was only formalized when, in 1841, the Polish embryologist Robert Remak boldly described forms of animal cell division when examining chick embryo red blood cell development. Later,... click to read more
When two kinases go for a dance
Protein phosphorylation is an important cellular regulatory mechanism which acts like a molecular switch in our cells. It is a process where a phosphate group, a small but very consequential chemical tag, is added to a protein. Think of it as turning a light switch... click to read more
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